Table 21.1
Representation of the structures of 25 quinazoline-based anti-EGFR compounds
Sr.
no.
Substitution at R1
Substitution at R2
Substitution at R3
Comments
References
1.
R1
S
O
O
O
R2
R3
O
N
Higher selectivity and enhanced anti-EGFR activity as
compared to gefitinib
Wu et al.
(2010)
2.
S
O
O
R1
O
R2
O
N
R3
3.
R1
H
N
O
O
R2
O
N
R3
O
The anticancer potential of the compounds was increased by
replacing benzene ring with a pyrrole ring and when position
6 or 7 of the quinazoline nucleus was substituted or branched
with basic side chain
Ahmad
(2017)
4.
R1
NH
O
O
R2
O
R3
O
N
5.
R1
NH
O
O
R2
O
R3
O
N
6.
R1
NH
O
O
R2
O
R3
O
N
7.
R1
NH
O
O
R2
O
R3
O
N
390
V. Panwar et al.